Cell micropatterning using photopolymerization with a liquid crystal device commercial projector
Cell micropatterning using photopolymerization with a liquid crystal device commercial projector
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DOI：
10.1016/j.biomaterials.2003.08.052
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发表时间：
2004-05-01
期刊：
影响因子：
14
通讯作者：
Okano, T
中科院分区：
文献类型：
--
作者：
Itoga, K;Yamato, M;Okano, T
光聚合已广泛用于表面微图案化。该技术通常需要光掩模和具有适当能量或滤光片的光源。为了表面光微图案的快速原型制作，我们通过修改市售液晶设备投影仪开发了一种新颖的设备。我们安装了图像缩小单元、可调节平台和光学监控单元来代替投影仪的图像扩展单元。该设备将计算机生成的图像投影到表面上，并对这些图案进行光聚合。可以使用在个人计算机上运行的各种软件轻松地制备微图案图像。利用所开发的光聚合装置，利用聚乙二醇二丙烯酸酯和可见光光聚合引发剂樟脑醌实现了聚乙二醇（PEG）的微图案化。在微图案表面上也实现了选择性细胞粘附控制。 (C) 2003 Elsevier Ltd. 保留所有权利。
Photopolymerization has been widely used for surface micropatterning. The technique often requires photomasks and light sources with appropriate energies or filters. For rapid prototyping of surface photo-micropatterning, we have developed a novel device by modifying a commercially available liquid crystal device projector. In place of the image expansion unit of the projector, we attached an image reduction unit, an adjustable stage, and an optical monitoring unit. The device projected computer-generated images onto surfaces and subjected these patterns to photopolymerization. Micropatterned images can be easily prepared with various software run on personal computers. With the developed photopolymerization device, micropatterning of poly(ethylene glycol) (PEG) was achieved with PEG-diacrylate and a visible light photopolymerization initiator, camphorquinone. Selective cell adhesion control was also achieved on the micropatterned surfaces. (C) 2003 Elsevier Ltd. All rights reserved.