Encoding of Eye Position in the Goldfish Horizontal Oculomotor Neural Integrator
Encoding of Eye Position in the Goldfish Horizontal Oculomotor Neural Integrator
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DOI：
10.1152/jn.00313.2010
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发表时间：
2011-02-01
影响因子：
2.5
通讯作者：
Baker, Robert
中科院分区：
文献类型：
--
作者：
Debowy, Owen;Baker, Robert
Debowy O，Baker R。金鱼水平动眼神经积分器中眼睛位置的编码。 J Neurophysiol 105: 896-909, 2011。首次发表于 2010 年 12 月 15 日； doi：10.1152/jn.00313.2010。研究了金鱼水平神经积分器在自发扫描扫视和注视行为期间的单眼组织。对神经元放电率的分析揭示了同侧（37%）、共轭（59%）和对侧（4%）眼位神经元的群体。当采用单眼视动刺激来最大化分离水平眼球运动时，抽样人群分别变为 57%、39% 和 4%。单眼眼睛跟踪可以在不同的增益和相位下引发，积分器时间常数可以通过向心（泄漏）或离心（不稳定）漂移视觉刺激为每只眼睛独立修改。后脑动眼神经积分器之间的急性中线分离不会影响单眼性或时间常数调谐，证实左眼和右眼位置在每个积分器内独立编码。这些发现共同表明，“同侧”和“共轭/对侧”整合神经元分别主要针对外展运动神经元和核间神经元。连合通路被提议选择共轭/对侧眼位神经元，并充当影响空眼位、动眼范围和扫视模式的前馈抑制。
Debowy O, Baker R. Encoding of eye position in the goldfish horizontal oculomotor neural integrator. J Neurophysiol 105: 896-909, 2011. First published December 15, 2010; doi: 10.1152/jn.00313.2010. Monocular organization of the goldfish horizontal neural integrator was studied during spontaneous scanning saccadic and fixation behaviors. Analysis of neuronal firing rates revealed a population of ipsilateral (37%), conjugate (59%), and contralateral (4%) eye position neurons. When monocular optokinetic stimuli were employed to maximize disjunctive horizontal eye movements, the sampled population changed to 57, 39, and 4%. Monocular eye tracking could be elicited at different gain and phase with the integrator time constant independently modified for each eye by either centripetal (leak) or centrifugal (instability) drifting visual stimuli. Acute midline separation between the hind-brain oculomotor integrators did not affect either monocularity or time constant tuning, corroborating that left and right eye positions are independently encoded within each integrator. Together these findings suggest that the "ipsilateral" and "conjugate/contralateral" integrator neurons primarily target abducens motoneurons and internuclear neurons, respectively. The commissural pathway is proposed to select the conjugate/contralateral eye position neurons and act as a feedfoward inhibition affecting null eye position, oculomotor range, and saccade pattern.