Behaviorally elicited heart rate reactivity and atherosclerosis in female cynomolgus monkeys (Macaca fascicularis).
Behaviorally elicited heart rate reactivity and atherosclerosis in female cynomolgus monkeys (Macaca fascicularis).
复制标题
行为引起雌性食蟹猴（猕猴）的心率反应性和动脉粥样硬化。
DOI：
10.1097/00006842-198905000-00005
复制
发表时间：
1989
影响因子：
3.3
通讯作者：
Clarkson,TB
中科院分区：
文献类型：
--
作者：
Manuck,SB;Kaplan,JR;Adams,MR;Clarkson,TB
我们以前报道过，在对标准实验室应激源表现出最大心率（HR）反应的动物中，胆固醇喂养的雄性食蟹猴（Macaca fascicularis）的冠状动脉粥样硬化加剧。在这里，我们报告了一个类似的关系，行为诱导的HR反应性和动脉粥样硬化的女性相同的物种。21只雌性猴子被喂食中度致动脉粥样硬化饮食30个月。在接近该阶段结束时，给动物配备心电图遥测装置，并在基线和应激条件下记录其HR。在涉及动物的威胁捕获和物理处理的标准挑战期间获得应激期HR测量值。尸检时，对左前降支、左回旋支和右冠状动脉的切片进行组织学检查。然后比较确定为高（n= 7）和低（n= 7）HR反应动物之间的平均内膜面积测量值。高HR反应性动物的冠状动脉粥样硬化程度显著高于低反应性动物;高反应性和低反应性猴子的右颈动脉分叉处的动脉粥样硬化程度也显著不同。各组在基线HR、血压和总胆固醇或HDL胆固醇浓度方面没有差异。然而，相对于低HR反应动物，高反应动物体重较轻，体重较轻，心脏重量较大（根据体重差异调整），行为攻击性较低，黄体期孕酮浓度较低。在采用所有21只研究动物数据的相关性分析中证实了这些关系。
We previously reported that the coronary atherosclerosis of cholesterol-fed, male cynomolgus monkeys (Macaca fascicularis) was exacerbated among animals that exhibited the largest heart rate (HR) reactions to a standard laboratory stressor. Here we report a similar relationship between behaviorally induced HR reactivity and atherosclerosis in females of the same species. Twenty-one female monkeys were fed a moderately atherogenic diet for 30 months. Near the end of this period, animals were fitted with electrocardiogram telemetry devices and their HRs were recorded under baseline and stressed conditions. Stress period HR measurements were obtained during a standard challenge involving threatened capture and physical handling of the animals. At necropsy, sections taken from the left anterior descending, left circumflex, and right coronary arteries were examined histologically. Mean intimal area measurements were then compared between animals identified as High (n= 7) and Low (n= 7) HR reactors. High HR reactive animals were found to have significantly greater coronary artery atherosclerosis than Low reactors; atherosclerosis at the right carotid bifurcation also differed significantly between High and Low reactive monkeys. Groups did not differ in baseline HR, blood pressure, and total or HDL cholesterol concentrations. Relative to Low HR reactors, however, High reactive animals weighed less and were less ponderous, had greater heart weights (adjusted for differences in body weight), were behaviorally less aggressive, and had lower luteal phase progesterone concentrations. These relationships were corroborated in correlation analyses employing data of all 21 study animals.