Sexual and temporal dynamics of molecular evolution in C. elegans development
Sexual and temporal dynamics of molecular evolution in C. elegans development
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DOI：
10.1093/molbev/msh267
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发表时间：
2005-01-01
影响因子：
10.7
通讯作者：
Ward, S
中科院分区：
文献类型：
--
作者：
Cutter, AD;Ward, S
解剖发育和分化的表型和分子细节是进化生物学中一个有几个世纪历史的话题。然而，对于在整个发育过程中——跨越时间、组织和性别——表达差异的基因的分子进化，我们还缺乏足够的理解。在这项研究中，我们研究了秀丽隐杆线虫个体发育过程中的基因进化动态，以及不同性别和配子类型之间基因表达的差异。利用全基因组基因表达发育时间序列鉴定的基因类别，并与同系物C. briggsae进行比较序列分析，我们证明了在生殖成熟后主要表达的基因比在发育早期表达的基因进化得更快，而在胚胎发生期间短暂表达的基因比其他胚胎转录物进化得更快。这些结果表明成熟后表达的基因选择较为宽松，符合衰老的突变积累模型。此外，与精子发生有关的基因比其他表型类型的基因进化得更快。雄性体细胞相关基因的平均进化速度表明，尽管这些雄性异株物种非常罕见，但选择作用于维持雄性，而精子基因的快速进化表明，性选择作用于精子的发育和功能。
Dissection of the phenotypic and molecular details of development and differentiation is a centuries-old topic in evolutionary biology. However, an adequate understanding is missing for the molecular evolution of genes that are expressed differentially throughout development-across time, tissues, and the sexes. In this study, we investigate the dynamics of gene evolution across Caenorhabditis elegans ontogeny and among genes expressed differentially between each sex and gamete type. Using gene classes identified by genome-wide gene expression developmental time series and comparative sequence analysis with the congener C. briggsae, we demonstrate that genes expressed predominantly after reproductive maturity evolve more rapidly than genes expressed earlier in development and that genes expressed transiently during embryogenesis evolve faster than other embryonic transcripts. These results are indicative of relaxed selection on genes expressed after maturity, in accord with the mutation-accumulation model of aging. Furthermore, genes involved in spermatogenesis reveal more rapid evolution than other phenotypic classes of genes. Average rates of evolution among male soma-related genes indicates that selection acts to maintain males in these androdioecious species, despite their rarity, and the rapid evolution of sperm genes suggests that sexual selection acts on sperm development and function.