A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity
A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity
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DOI：
10.1084/jem.20102358
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发表时间：
2011-08-29
影响因子：
15.3
通讯作者：
Noelle, Randolph J.
中科院分区：
文献类型：
--
作者：
Pino-Lagos, Karina;Guo, Yanxia;Noelle, Randolph J.
已知维生素A及其代谢产物视黄酸（RA）是宿主防御所必需的。然而，RA如何控制炎症的机制还不完全清楚。本研究中的发现表明，RA信号传导与炎症的发展同时发生。在疫苗接种和同种异体移植排斥模型中，全身成像显示RA信号传导在时间和空间上局限于炎症部位。T细胞中RA信号传导的条件性消融显著干扰CD4（+）T细胞效应器功能、迁移和极性。这些发现为RA作为直接调控CD4（+）T细胞分化和免疫的介质的作用提供了新的视角。
It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4(+) T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4(+) T cell differentiation and immunity.