New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China
New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China
复制标题
高致病性禽流感H5N1病毒在中国中亚和东亚-澳大利亚航线之间东西向传播的新证据
DOI：
10.1080/22221751.2019.1623719
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发表时间：
2019
影响因子：
13.2
通讯作者：
Lu Jun
中科院分区：
文献类型：
--
作者：
Meng Weiyue;Yang Qiqi;Vrancken Bram;Chen Zhuo;Liu Dongping;Chen Lixia;Zhao Xiang;Francois Sarah;Ma Tian;Gao Ruyi;Ru Wendong;Li Yunfeng;He Hongxuan;Zhang Guogang;Tian Huaiyu;Lu Jun
高致病性禽流感（HPAI）H5 N1病毒的传播与东亚-澳大拉西亚（EA）和中亚（CA）航线上的野禽迁徙有关。然而，H5 N1病毒在这两条飞行路线之间的传播仍然不清楚。本文利用卫星跟踪资料，获得了青海湖地区（沿着EA航道）繁殖的7只斑头雁和3只大黑嘴鸥，以及在三门峡库区（CA航道）越冬的20只大天鹅的活动情况。从2015年7月青海湖H5 N1禽流感暴发后采集的2688份野鸟样本中，从斑头雁中分离到4株H5 N1病毒基因组。系统进化分析结果表明，这些H5 N1亚型病毒属于2.3.2.1c进化枝，与2015年1月从沿着三门峡库区死亡大天鹅中分离到的A/whooper swan/Henan/SMX 1/2015（H5 N1）病毒同源性为99.76%~ 100.00%。此外，H5 N1爆发的时间与春季迁徙的巧合，再加上系统发育证据，提供了新的证据，高致病性禽流感H5 N1从东向西传播之间的EA和CA的迁移飞行路线的中国。
The spread of highly pathogenic avian influenza (HPAI) H5N1 virus is associated with wild fowl migration in East Asian-Australasian (EA) and Central Asian (CA) flyways. However, the spread of H5N1 virus between the two flyways is still unclear. Here, the movements of wild waterfowl were obtained from satellite tracking data covering seven bar-headed geese and three great black-headed gulls breeding in the Qinghai Lake area (along the EA flyway), and 20 whooper swans wintering in the Sanmenxia Reservoir area (at the CA flyway). From the 2688 samples that were screened from wild birds at Qinghai Lake after an outbreak of H5N1 in July 2015, four genomes of H5N1 virus were obtained from bar-headed geese. The results of phylogenetic analysis indicated that these H5N1 viruses belonged to clade 2.3.2.1c and their gene fragments were highly homologous with A/whooper swan/Henan/SMX1/2015 (H5N1) virus (ranging from 99.76% to 100.00%) isolated from a dead whooper swan from the Sanmenxia Reservoir area along the EA flyway in January 2015. Furthermore, the coincidental timing of the H5N1 outbreak with spring migration, together with phylogenetic evidence, provided new evidence of the east-to-west spread of HPAI H5N1 between the EA and CA migratory flyways of China.