Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension.
Furosemide compared with hydrochlorothiazide. Long-term treatment of hypertension.
复制标题
呋塞米与氢氯噻嗪的比较。
DOI：
10.1001/jama.1978.03290170045023
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
E. Freis
中科院分区：
文献类型：
--
作者：
M. Araoye;M. Y. Chang;I. Khatri;E. Freis
在一项双盲交叉研究中，比较了高血压患者中速尿（40 毫克，每日两次）与氢氯噻嗪（50 毫克，每日两次）的疗效。在三个月的治疗期间，氢氯噻嗪和呋塞米均显着降低了血压（BP）。然而，氢氯噻嗪的血压下降幅度始终大于呋塞米，尽管差异仅在收缩压方面显着。氢氯噻嗪较高的抗高血压功效可能与其作用时间较长有关，可以产生更持续的利尿作用，从而在整个 24 小时内维持细胞外液量减少。
In a double-blind crossover study, the effectiveness of furosemide, 40 mg twice daily, was compared with hydrochlorothiazide, 50 mg twice daily, in hypertensive patients. Both hydrochlorothiazide and furosemide significantly reduced blood pressure (BP) during three months of therapy. However, the fall in BP was consistently greater with hydrochlorothiazide than with furosemide, although the difference was significant only with respect to systolic BP. The somewhat greater antihypertensive effectiveness of hydrochlorothiazide may be related to its longer action permitting a more continuous diuretic effect and, hence, maintenance of reduced extracellular fluid volume throughout the 24-hour period.