Elevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.
Elevation of Tim-3 and PD-1 expression on T cells appears early in HIV infection, and differential Tim-3 and PD-1 expression patterns can be induced by common γ -chain cytokines.
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T 细胞上 Tim-3 和 PD-1 表达的升高出现在 HIV 感染早期，常见的 γ 链细胞因子可诱导 Tim-3 和 PD-1 表达模式的差异
DOI：
10.1155/2015/916936
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发表时间：
2015
影响因子：
--
通讯作者：
Shang H
中科院分区：
文献类型：
--
作者：
Zhang ZN;Zhu ML;Chen YH;Fu YJ;Zhang TW;Jiang YJ;Chu ZX;Shang H
目的。探讨TIM-3和PD-1的差异表达模式与HIV疾病进展的关系，以及常见γ链细胞因子对T细胞TIM-3和PD-1表达模式的影响。方法：研究方法。检测早期和慢性HIV感染者T细胞表面TIM-3/PD-1的表达。研究γ链细胞因子诱导不同TIM-3和PD-1表达模式的T细胞的表达水平和功能变化。结果。T细胞上TIM-3和PD-1的差异表达模式在HIV感染早期就已出现。TIM-3和PD-1(TIM-3+PD-1+)的共同表达与HIV感染过程中更严重的T细胞耗竭有关。体外刺激常见的γ链细胞因子可诱导T细胞上TIM-3和PD-1的差异表达。共同γ链IL-2对TIM-3和PD-1表达的增强可抑制HIV Gag和Tcr再刺激T细胞的功能，而不能抑制IL-2的再刺激。结论。T细胞上TIM-3和PD-1差异表达模式的升高代表T细胞耗竭状态，可由常见的γ链细胞因子诱导。这些发现提供了对艾滋病毒发病机制的见解，并有助于为免疫干预策略提供信息。
Purpose. To explore the association between differential Tim-3 and PD-1 expression patterns and HIV disease progression, and to investigate the impact of common γ-chain cytokines on Tim-3 and PD-1 expression patterns on T cells. Methods. Tim-3/PD-1 expression on the T cells of patients with early and chronic HIV infections was detected. The expression levels and functional profiles of T cells with differential Tim-3 and PD-1 expression patterns induced by γ-chain cytokines were studied. Results. The elevation of differential Tim-3 and PD-1 expression patterns on T cells appeared early in HIV infection. Co-expression of Tim-3 and PD-1 (Tim-3+PD-1+) correlates with more severe exhaustion of T cells during HIV infection. In vitro stimulation of common γ-chain cytokines can induce differential expression patterns of Tim-3 and PD-1 on T cells. The enhancement of Tim-3 and PD-1 expression by common γ-chain IL-2 can inhibit the function of T cells re-stimulated by HIV gag and TCR, not by the re-stimulation of IL-2. Conclusions. The elevation of differential Tim-3 and PD-1 expression patterns on T cells represents a state of T cell exhaustion and can be induced by common γ-chain cytokines. These findings provide insights into HIV pathogenesis and help inform immune intervention strategies.