ASSOCIATION OF THE APC TUMOR-SUPPRESSOR PROTEIN WITH CATENINS
ASSOCIATION OF THE APC TUMOR-SUPPRESSOR PROTEIN WITH CATENINS
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DOI：
10.1126/science.8259519
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发表时间：
1993-12-10
期刊：
影响因子：
56.9
通讯作者：
KINZLER, KW
中科院分区：
文献类型：
--
作者：
SU, LK;VOGELSTEIN, B;KINZLER, KW
APC的突变似乎启动散发和遗传形式的人类结直肠癌。虽然这些突变已得到很好的表征，但对APC基因产物的功能知之甚少。通过核苷酸序列分析和肽图谱分析，确定了与APC相关的两种细胞蛋白，即E-钙粘蛋白相关蛋白α-和β-连环蛋白。含有15个氨基酸重复的APC的27个残基片段足以与连环蛋白相互作用。这些结果表明肿瘤发生和细胞粘附之间存在重要联系。
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were identified by nucleotide sequence analysis and peptide mapping as the E-cadherin-associated proteins alpha- and beta-catenin. A 27-residue fragment of APC containing a 15-amino acid repeat was sufficient for the interaction with the catenins. These results suggest an important link between tumor initiation and cell adhesion.