Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues

Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues
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用于高选择性和灵敏检测活细胞和心脏组织中硫化氢的荧光探针

DOI:
10.1039/c2an36113b
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发表时间:
2013-01-01
期刊:
影响因子:
4.2
通讯作者:
Tang, Xinjing
Tang, Xinjing
中科院分区:
化学2区
文献类型:
--
作者:
Chen, Bifeng;Li, Wei;Tang, Xinjing

文献摘要

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A coumarin-based fluorescence chemoprobe was developed and evaluated for the selective and sensitive detection of hydrogen sulfide in degassed PBS buffers and fetal bovine serum. Fluorescence detection of hydrogen sulfide in living cells was also successfully achieved using two-photon confocal fluorescence imaging. Further in situ visualization of endogenous H2S was realized in cardiac tissues of normal rats and atherosclerosis (AS) rats.