Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain
Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain
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DOI：
10.1002/ana.20317
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发表时间：
2005-01-01
影响因子：
11.2
通讯作者：
Takahashi, K
中科院分区：
文献类型：
--
作者：
Pan, JW;Takahashi, K
由于细胞和提取物数据表明n -乙酰天冬氨酸（NAA）反映神经元线粒体功能，我们评估了15名健康志愿者海马和枕叶中NAA、高能磷酸盐和ADP水平之间的定量关系。ADP水平计算使用肌酸激酶平衡和定量P-31和总肌酸测量。采用高场定量MR光谱成像，我们发现海马体内NAA和ADP浓度分别为9.7 +/- 1.5mM和35 +/- 8muM。枕叶NAA和ADP分别为11.9 +/- 1.9mM和32 +/- 12muM。海马体NAA与ADP呈正相关，R = +0.80, p < 2 × 10（-7）。相邻海马NAA体素与ADP的相关性R = +0.62, p < 3 × 10(-4)，枕叶NAA与ADP的相关性R = +0.67, p < 5 × 10（-5）。NAA与ATP、磷酸肌酸均无显著相关性。NAA与ADP的正相关表明，能量学可能调节线粒体功能的定向过程。
Because cellular and extract data have suggested that N-acetylaspartate (NAA) reflects neuronal mitochondrial function, we evaluated the quantitative relationship between NAA, high-energy phosphates, and ADP levels in the hippocampus and occipital lobe of 15 healthy volunteers. The ADP levels are calculated using the creatine kinase equilibrium and quantified P-31 and total creatine measurements. Using high-field quantitative MR spectroscopic imaging, we find that NAA and ADP concentrations in the hippocampal body are 9.7 +/- 1.5mM and 35 +/- 8muM, respectively. In the occipital lobe, NAA and ADP are 11.9 +/- 1.9mM and 32 +/- 12muM, respectively. There is a statistically significant positive correlation between NAA and ADP, with R = +0.80, p < 2 X 10(-7) in the hippocampal body. In an adjacent hippocampal NAA voxel, the correlation between NAA and ADP had a R = +0.62, p < 3 X 10(-4), whereas, in the occipital lobe, R = +0.67, p < 5 X 10(-5). There was no significant relationship NAA and either ATP or phosphocreatine. This positive relationship of NAA with ADP suggests a directional process wherein energetics may modulate mitochondrial function.