Sensory afferent processing in multi-responsive DRG neurons.
Sensory afferent processing in multi-responsive DRG neurons.
复制标题
多反应 DRG 神经元的感觉传入处理。
作者：
E. Senba;H. Kashiba
分子和神经生物学技术的最新进展揭示了 DRG 神经元的多重反应性质。这些神经元的存活、表型表达和电特性通过其特定受体受到多种物质的控制。在组织炎症或神经损伤等病理条件下，DRG 神经元通过受体系统的动态重建来改变其反应能力。这种重建是由环境刺激引发的。因此，多模式伤害感受器的特性可以根据环境条件而改变。该机制的整个故事尚未公开。为了理解这一机制，识别 DRG 神经元中的各种受体 mRNA、受体蛋白的精确定位、这些受体的合成位点和配体的供应途径至关重要。
The recent advance in molecular and neurobiological techniques disclosed the multi-responsive nature of DRG neurons. The survival, phenotype expression and electrical properties of these neurons are under the control of a variety of substances through their specific receptors. In pathological conditions, such as tissue inflammation or nerve injury, DRG neurons change their responsiveness through the dynamic reconstruction of their receptor system. This reconstruction is initiated by environmental stimuli. Thus the properties of polymodal nociceptors can be altered according to the environmental conditions. The whole story of this mechanism is not disclosed yet. In order to understand this mechanism, it is basically important to identify various receptor mRNAs in DRG neurons, precise localization of receptor proteins, site of synthesis and route of supply of ligands for these receptors.