Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway
Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway
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DOI：
10.1016/j.bmc.2010.01.039
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Cashman, John R.
中科院分区：
文献类型：
--
作者：
Okolotowicz, Karl J.;Shi, Ranxin;Cashman, John R.
Dysregulated antigen receptor-mediated NF-kappa B activation can contribute to development of autoimmunity, chronic inflammation, and malignancy. A chemical biology screening strategy has identified a substituted benzimidazole that selectively inhibits antigen receptor-mediated NF-kappa B activation without blocking other NF-kappa B activation pathways. A library of analogs was synthesized and the structure-activity relationship and metabolic stability for the series is presented. (C) 2010 Elsevier Ltd. All rights reserved.
