Are changes in sexual functioning during midlife due to aging or menopause?
Are changes in sexual functioning during midlife due to aging or menopause?
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DOI：
10.1016/s0015-0282(01)01978-1
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发表时间：
2001-09-01
影响因子：
6.7
通讯作者：
Burger, H
中科院分区：
文献类型：
--
作者：
Dennerstein, L;Dudley, E;Burger, H
目的：确定女性中年时期性功能的改变是否与年龄或更年期有关。设计：前瞻性观察性研究。地点：以人群为基础的样本，在家中评估。患者(S)：438名澳大利亚出生的女性，年龄45-55岁，基线仍有月经。197名受试者研究了自然绝经过渡的影响。对照组44例，绝经前或围绝经期早期7年。对照组(B组，n=422)绝经后5年以上。干预(S)：无；问卷调查和每年采血。主要结果测量(S)：简明版个人经历问卷。结果(S)：到围绝经期晚期，我们衍生的性反应性因素和总分显著下降，而配偶的问题因子增加。到绝经后阶段，性反应性、性行为频度、性欲和性欲在总分中的得分进一步下降，而阴道性交困难和伴侣问题显著增加。性反应性--在两个对照组中均显著降低。结论(S)：性反应性受到年龄和绝经转变的双重不利影响。当女性进入绝经后时，女性性功能的其他领域受到了严重的不利影响。与伴侣的关系和他的性行为能力受到更年期转变的不利影响。(Fertil Steril(R)2001；76：456-60。(C)2001年美国生殖医学会。)。
Objective: To determine whether changes in women's sexual functioning during midlife are due to aging or menopause.Design: Prospective, observational study.Setting: Population-based sample assessed in own homes.Patient(s): Four hundred thirty-eight Australian-born women aged 45-55 years and still menstruating at baseline. One hundred ninety-seven were studied for effects of the natural menopausal transition. Control group A (n=44) remained premenopausal or early perimenopausal for 7 years. Control group B (n=422) remained postmenopausal over 5 years.Intervention(s): Nil; questionnaires and blood sampling annually.Main Outcome Measure(s): Shortened version of the Personal Experiences Questionnaire.Result(s): By the late perimenopause, there was a significant decline in the factors we had derived of sexual responsivity and total score, and there was an increase in the partner's problems factor. By the postmenopausal phase, there was a further decline in the factors sexual responsivity, frequency of sexual activities, libido, and ty in the total score, and a significant increase in vaginal dyspareunia and partner's problems. Sexual responsivity-significantly declined in both control groups.Conclusion(s): Sexual responsivity is adversely affected by both aging and the menopausal transition. Other domains of female sexual functioning were significantly adversely affected when the women became postmenopausal. The relationship with the partner and his ability to perform sexually is adversely affected by the menopausal transition. (Fertil Steril(R) 2001;76:456-60. (C) 2001 by American Society for Reproductive Medicine.).