Collagen Membrane and Immune Response in Guided Bone Regeneration: Recent Progress and Perspectives
Collagen Membrane and Immune Response in Guided Bone Regeneration: Recent Progress and Perspectives
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引导骨再生中的胶原膜和免疫反应：最新进展和展望
DOI：
10.1089/ten.teb.2016.0463
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发表时间：
2017-10-01
影响因子：
6.4
通讯作者：
Man, Yi
中科院分区：
文献类型：
--
作者：
Chu, Chenyu;Deng, Jia;Man, Yi
胶原是胶原膜的重要组成部分，也是细胞外基质（ECM）。大多数先前的研究集中于将胶原蛋白膜与各种交联剂、接枝材料和细胞因子结合以增强其机械性能和生物活性。此外，胶原蛋白膜通常被设计成使涉及巨噬细胞的异物反应最小化。然而，最近发现巨噬细胞在骨再生过程中起着关键作用，这是基于它们极化成促炎和抗炎表型。由于能够调节巨噬细胞极化并介导促炎和抗炎微环境的平衡，免疫应答胶原蛋白膜可能是促进骨再生的创新策略。本文简要介绍了胶原蛋白膜和巨噬细胞的研究背景，阐述了免疫反应性胶原蛋白的调节和研究现状，阐述了胶原蛋白与巨噬细胞相互作用的潜力和进一步研究免疫反应性胶原蛋白膜的必要性。
Collagen is one of the important components of collagen membranes as well as the extracellular matrix (ECM). Most previous studies have focused on combining collagen membranes with various cross-linking agents, grafting materials, and cytokines to enhance their mechanical properties and bioactivities. Moreover, collagen membranes are often designed to minimize foreign body reactions involving macrophages. However, macrophages were recently found to play a pivotal role during bone regeneration based on their polarization into both proinflammatory and anti-inflammatory phenotypes. Because of the abilities to modulate macrophage polarization and mediate the balance of proinflammatory and anti-inflammatory microenvironments, immune-responsive collagen membranes may be an innovative strategy for promoting bone regeneration. Herein, following a brief review of collagen membranes and the background of macrophages, recent modulations and studies of immune-responsive collagen are described to express the potential of collagen interacting with macrophages and the necessity of further studies in the field of immune-responsive collagen membranes.