Components of socioeconomic risk associated with head and neck cancer: A population-based case-control study in Scotland
Components of socioeconomic risk associated with head and neck cancer: A population-based case-control study in Scotland
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DOI：
10.1016/j.bjoms.2009.03.020
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发表时间：
2010-01-01
影响因子：
1.8
通讯作者：
McKinney, Patricia A.
中科院分区：
文献类型：
--
作者：
Conway, David I.;McMahon, Alex D.;McKinney, Patricia A.
社会经济环境与头颈癌风险之间的复杂联系尚未得到充分探讨。我们调查了社会阶层的组成部分及其对头颈部癌症风险的相对影响，研究了103例患者（年龄范围24-80岁），他们在2002年4月至2004年12月期间被诊断患有头颈部癌症，91名对照者从全科医生的名单中随机选择。在个人访谈中收集有关职业、教育、吸烟和饮酒的信息。社会经济情况是在个人一级（教育、职业社会阶层、失业）和以地区为基础的贫困措施来衡量的。采用非条件Logistic回归和多变量分析计算比值比（OR）和95%置信区间（0）。生活在最贫困地区的人（OR = 4.66，95%CI 1.79-12.18）和失业者（OR = 2.27，95%CI 1.21-4.26）的癌症风险显著高于高教育水平的人（OR = 0.17，95%CI 0.05-0.58）。当对吸烟和饮酒进行调整时，所有社会阶层的衡量标准都失去了意义。多因素分析中吸烟是唯一显著的危险因素（OR = 15.53，95%CI 5.36-44.99）。头颈癌的高风险一直与贫困的社会经济环境有关，并且与特定成分有很强的联系，但吸烟主导了整体风险。我们提出了未来社会经济分析的框架。(C)2009年英国口腔颌面外科医师协会。由爱思唯尔有限公司出版。保留所有权利。
The complex associations between socioeconomic circumstances and risk for head and neck cancer are under-explored. We investigated components of social class and their relative influence on the risk of head and neck cancers by studying 103 patients (age range 24-80 years) who had been diagnosed with cancer of the head and neck between April 2002 and December 2004, and 91 controls who were randomly selected from general practitioners' lists. Information about occupation, education, smoking, and alcohol consumption was collected at personal interview. Socioeconomic circumstances were measured at an individual level (education, occupational social class, unemployment), and by area-based measures of deprivation. Odds ratios (OR) and 95% confidence intervals (0) were computed using unconditional logistic regression and multivariate analyses. People living in the most deprived areas (OR = 4.66, 95% CI 1.79-12.18); and those who were unemployed (OR = 2.27, 95% CI 1.21-4.26) had a significantly higher risk of cancer than those with high levels of educational attainment (OR = 0.17, 95% CI 0.05-0.58). Significance was lost for all measures of social class when adjustments were made for smoking and consumption of alcohol. Smoking was the only significant risk factor (OR = 15.53, 95% CI 5.36-44.99) in the multivariate analysis. A high risk of head and neck cancer was consistently associated with poor socioeconomic circumstances, and there were strong links for specific components however smoking dominated the overall profile of risk. We propose a framework for future socioeconomic analyses. (C) 2009 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.