Crossover Reactions Between Synthetic Replicators Yield Active and Inactive Recombinants
Crossover Reactions Between Synthetic Replicators Yield Active and Inactive Recombinants
复制标题
合成复制子之间的交叉反应产生活性和非活性重组体
作者：
Qing Feng;Tae Kyo Park;J. Rebek
自复制分子可以通过两个互补亚基的共价键合成，从而形成自互补结构。互补性是指两个亚基之间的大小、形状和弱分子间作用于分子识别的力。为了给分子进化提供一个模型系统，这些反应产生了新的结构类型。新的重组体催化自身形成的能力（或无能）被证明是其分子形状的结果。
Self-replicating molecules can be synthesized through the covalent linkage of two complementary subunits to give a self-complementary structure. Complementarity refers to sizes, shapes, and the weak intermolecular forces involved in molecular recognition between the two subunits. In order to provide a model system for evolution at the molecular These reactions gave rise to new structural types. The ability (or inability) of the new recombinants to catalyze their own formation is shown to be a consequence of their molecular shapes.