The inflammation influence on corneal surface after frontalis suspension surgery
The inflammation influence on corneal surface after frontalis suspension surgery
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额肌悬吊术后炎症对角膜表面的影响
DOI：
10.18240/ijo.2018.09.10
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发表时间：
2018-09-18
影响因子：
1.4
通讯作者：
Lu, Rong
中科院分区：
文献类型：
--
作者：
Li, Kang;Zhang, Xin-Chun;Lu, Rong
目的：通过分析额肌瓣悬吊术的临床特点和炎性细胞因子，探讨额肌瓣悬吊术对眼表的影响。25例31眼重度先天性上睑下垂患者接受额肌瓣悬吊术，随访至少6个月。主要观察指标为边缘反射距离1（MRD 1）、兔眼程度、眼表疾病指数（OSDI）、荧光素染色（FI）、泪膜破裂时间（BUT）、Schirmer I试验和炎性细胞因子测定。术后1 wk OSDI评分显著升高，术后4 wk下降。Fl评分反映了16例术后早期角膜上皮缺损。BUT和Schirmer I测试值保持稳定，与术前相比未显示变化。术后1周结膜上皮细胞内炎性细胞因子IL-1 β、IL-6、IL-8、TNF-α和IL-17 A均显著升高（P
AIM: To study the influence of frontalis muscle flap suspension on ocular surface by analyzing the clinical features and inflammatory cytokines.METHODS: A prospective, observational case series. Thirty-one eyes of 25 patients with severe congenital blepharoptosis who underwent frontalis muscle flap suspension surgery with at least 6mo of follow-up were included in the study. The main outcome measures were margin reflex distance 1 (MRD1), degree of lagophthalmos, ocular surface disease index (OSDI), fluorescein staining (Fl), tear break-up time (BUT), Schirmer I test, and inflammatory cytokine assay.RESULTS: The degrees of lagophthalmos significantly increased after surgery. The OSDI scores significantly increased 1wk postoperatively and then decreased 4wk after operation. The Fl scores reflected corneal epithelial defects in sixteen patients at early stage postoperatively. The BUT and Schirmer I test values remained stable and did not show change compared to those before surgery. The inflammatory cytokines in conjunctival epithelial cells (including IL-1 beta, IL-6, IL-8, TNF-alpha, and IL-17A) significantly increased 1wk after the surgery (P