Proteasomes in immune cells: more than peptide producers?
Proteasomes in immune cells: more than peptide producers?
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DOI：
10.1038/nri2687
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发表时间：
2010-01-01
影响因子：
100.3
通讯作者：
Basler, Michael
中科院分区：
文献类型：
--
作者：
Groettrup, Marcus;Kirk, Christopher J.;Basler, Michael
当用促炎细胞因子刺激细胞时，它们组成型表达的蛋白酶体中的大部分被免疫蛋白酶体取代，这增加了用于呈递在MHC I类分子上的肽的产生。此外，皮质胸腺上皮细胞选择性表达一种称为胸腺蛋白酶体的蛋白酶体，这是胸腺细胞阳性选择所必需的。在这里，我们讨论了这些专门类型的蛋白酶体如何塑造细胞毒性T淋巴细胞的T细胞受体库，并提出免疫蛋白酶体的功能，除了抗原处理，影响细胞因子的产生和T细胞分化，生存和功能。我们还讨论了免疫蛋白酶体抑制剂如何抑制自身免疫性疾病中不需要的T细胞反应。
When cells are stimulated with pro-inflammatory cytokines, most of their constitutively expressed proteasomes are replaced with immunoproteasomes, which increase the production of peptides for presentation on MHC class I molecules. In addition, cortical thymic epithelial cells selectively express a type of proteasome known as the thymoproteasome that is required for the positive selection of thymocytes. Here, we discuss how these specialized types of proteasome shape the T cell receptor repertoire of cytotoxic T lymphocytes and propose that immunoproteasomes have functions, in addition to antigen processing, that influence cytokine production and T cell differentiation, survival and function. We also discuss how inhibitors of immunoproteasomes can suppress undesired T cell responses in autoimmune diseases.