Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.
Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.
复制标题
克霉唑可抑制白色念珠菌感染引起的阴道炎症和中性粒细胞浸润。
DOI：
10.1128/aac.01244-13
复制
发表时间：
2013
影响因子：
4.9
通讯作者：
Wilson D
中科院分区：
文献类型：
--
作者：
Wilson D
由白色念珠菌引起的外阴阴道念珠菌病（VVC）的病理与非保护性炎症反应有关，通常用克霉唑治疗。我们研究了氯霉唑解决VVC的机制。低水平的克霉唑不能阻断真菌生长，但会抑制“危险反应”转录因子c-Fos的表达，阻断促炎细胞因子的产生，并抑制中性粒细胞向感染部位的浸润。
The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a “danger response” transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.