Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice
Effect of low dose of vinclozolin on reproductive tract development and sperm parameters in CD1 outbred mice
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DOI：
10.1016/j.reprotox.2008.09.007
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Peknicova, Jana
中科院分区：
文献类型：
--
作者：
Elzeinova, Fatima;Novakova, Vendula;Peknicova, Jana
研究了小剂量长春花碱对CD1小鼠妊娠期(VIN-GD15-22)和青春期(VIN-PND23-44)生殖道发育的影响。我们发现，两个实验组的肛门距离、前列腺重量和睾丸病理都有所下降。精子计数分别降至46%(VIN-GD)和81%(VIN-PND)，顶体状态(用抗顶体抗体评价)均较对照组(100%)下降89%。精子头部异常分别增加了约18%和13%。在这方面，一些基因的表达发生了变化(arosome相关基因(ACR)、凋亡相关基因(p53、p21))。总而言之，低剂量的长春花碱影响了两个试验组的生殖道、精子参数和选定基因的表达。(C)2008 Elsevier Inc.保留所有权利。
The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups. (C) 2008 Elsevier Inc. All rights reserved.