Environmentally-regulated genes of hypertension
Environmentally-regulated genes of hypertension
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DOI：
10.3109/10641969609088962
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发表时间：
1996-04-01
影响因子：
12.3
通讯作者：
Hamet, P
中科院分区：
文献类型：
--
作者：
Hamet, P
近年来，高血压的几个单基因病因已被确定，但大多数情况下，这种疾病是多基因的，可能是异质性的。环境影响约占血压变异的2/3，通常被认为是在表型修饰水平上施加的，是决定血压的遗传位点效应的叠加。这里提出的概念是，在很大程度上，环境与基因相互作用，影响其表达。特别感兴趣的是在人类和实验性高血压中差异表达的应激基因。它们可能构成血压和心脏重量的候选基因，在基因表达水平上受到环境应激的影响。
Several monogenetic causes of hypertension have recently been identified, but for the most part, the disease is of polygenic and possibly heterogenous character. The environmental impact, representing about 2/3 of blood pressure variance, is usually thought to be exerted at the level of phenotypic modification, additive to the effect of genetic loci determining blood pressure. The concept presented here is that for a significant part, the environment interacts with genes, influencing their expression. Of particular interest are stress genes expressed differentially in human and experimental hypertension. They may constitute candidate genes of blood pressure and heart weight, influenced by environmental stressors at the level of gene expression.