RESOLUTION MEASUREMENT FOR ION MOBILITY SPECTROMETRY
RESOLUTION MEASUREMENT FOR ION MOBILITY SPECTROMETRY
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DOI：
10.1021/ac00286a023
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发表时间：
1985-01-01
影响因子：
7.4
通讯作者：
HILL, HH
中科院分区：
文献类型：
--
作者：
ROKUSHIKA, S;HATANO, H;HILL, HH
单峰方法用于计算分辨率值，该分辨率值等于在进行测量的峰之前可以分离的峰的理论数量（并且具有相同的尺寸）。该 IMS 分辨率可以通过 R= l/2Wh 计算，其中 R 是 IMS 分辨率，t 是以毫秒为单位的离子漂移时间，tVh 是以毫秒为单位的半高峰的时间宽度。 IMS 分辨率对各种仪器参数依赖性的方程推导为 R= f/[IV02+(44.2 kTt/qEL) 2] 1/2，其中 W0 为初始离子平面的峰宽，k 为玻尔兹曼常数，T 为绝对温度，t 为离子的漂移时间，q 为离子上的电荷，E 为离子漂移区的电场，L 为离子的长度。离子漂移区。每当离子淌度光谱法（也称为等离子体色谱法）作为一种分析技术进行讨论时，就会出现有关其分辨率的问题。这项技术到底能将一种离子与另一种离子分离多少呢？其分辨率与质谱的分辨率相比如何？或者说，其分离能力是否应该从色谱分离度来讨论？
A single peak method Is used tocalculate a resolution value equal to the theoretical number of peaks that can be sepa-rated prior to (and with the same dimensions as) the peak from which the measurements are made. This IMS resolution can be calculated by R= l/2Wh, where R Is IMS resolution, t Is the Ion drift time In milliseconds, and tVh Is the temporal width of the peak at half height In milliseconds. An equation showing the dependence of IMS resolution on various In-strumental parameters Is derived to beR= f/[IV02+(44.2 kTt/qEL) 2] 1/2, where W0 Is the peak width of the Initial Ion plane, k is Boltzmann’s constant, T Is absolute temperature, tIs the drift time of the Ion, q Is thecharge on the Ion, E Is the electric field In the Ion drift region, and L Is the length of the Ion drift region.Whenever ion mobility spectrometry, also known as plasma chromatography, is discussed as an analytical technique, questions arise concerning its resolution. Just how well can this technique separate one ion from another? How does its resolution compare with that of mass spectrometry? Or, should its separation power be discussed in terms of chromatographic resolution?