Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy.
Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy.
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DOI：
10.1186/1742-4690-8-97
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发表时间：
2011-12-05
期刊：
影响因子：
3.3
通讯作者：
Blankson JN
中科院分区：
文献类型：
--
作者：
Salgado M;Rabi SA;O'Connell KA;Buckheit RW 3rd;Bailey JR;Chaudhry AA;Breaud AR;Marzinke MA;Clarke W;Margolick JB;Siliciano RF;Blankson JN
While initiation of highly active antiretroviral therapy (HAART) during primary HIV-1 infection occasionally results in transient control of viral replication after treatment interruption, the vast majority of patients eventually experience a rebound in plasma viremia. Here we report a case of a patient who was started on HAART during symptomatic primary infection and who has subsequently maintained viral loads of < 50 copies/mL for more than nine years after the cessation of treatment. This patient had a high baseline viral load and has maintained a relatively high frequency of latently infected CD4+ T cells. In addition, he does not have any known protective HLA alleles. Thus it is unlikely that he was destined to become a natural elite controller or suppressor. The mechanism of control of viral replication is unclear; he is infected with a CCR5/CXCR4 dual-tropic virus that is fully replication-competent in vitro. In addition, his spouse, who transmitted the virus to him, developed AIDS. The patient's CD4+ T cells are fully susceptible to HIV-1 infection, and he has low titers of neutralizing antibodies to heterologous and autologous HIV-1 isolates. Furthermore, his CD8+ T cells do not have potent HIV suppressive activity. This report suggests that some patients may be capable of controlling pathogenic HIV-1 isolates for extended periods of time after the cessation of HAART through a mechanism that is distinct from the potent cytotoxic T lymphocyte (CTL) mediated suppression that has been reported in many elite suppressors.
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影响因子：
15.8
作者：
Kaufmann DE;Lichterfeld M;Altfeld M;Addo MM;Johnston MN;Lee PK;Wagner BS;Kalife ET;Strick D;Rosenberg ES;Walker BD
通讯作者：
Walker BD
DOI：
10.1086/653677
发表时间：
2010-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Julg B;Pereyra F;Buzón MJ;Piechocka-Trocha A;Clark MJ;Baker BM;Lian J;Miura T;Martinez-Picado J;Addo MM;Walker BD
通讯作者：
Walker BD
影响因子：
30.8
作者：
Martin, MP;Gao, XJ;Carrington, M
通讯作者：
Carrington, M
影响因子：
15.9
作者：
Chen, Huabiao;Li, Chun;Lichterfeld, Mathias
通讯作者：
Lichterfeld, Mathias
影响因子：
5.4
作者：
Brockman, Mark A.;Schneidewind, Arne;Allen, Todd M.
通讯作者：
Allen, Todd M.