Multivariate Analyses of Urinary Calculi Composition: A 13-Year Single-Center Study
Multivariate Analyses of Urinary Calculi Composition: A 13-Year Single-Center Study
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泌尿系结石成分的多变量分析：一项为期 13 年的单中心研究
DOI：
10.1002/jcla.21950
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发表时间：
2016-11-01
影响因子：
2.7
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Yang, Xiong;Zhang, Changwen;Xu, Yong
背景泌尿系结石的发病率和患病率在世界范围内呈上升趋势。与过去相比，最近的尿石症患者的人口统计学组成是惊人的不同。此外，最近的临床研究表明季节性周期可能会影响结石成分的分布。方法我们试图根据尿结石分析来确定尿石症发病机制的趋势。在2002年至2014年期间，我们中心共收集了2，383份来自不同患者的合格泌尿系结石样本。红外光谱法用于尿结石分析。采用Logistic回归分析方法，对13年来我国北方地区泌尿系结石构成与月份（季节）、性别、年龄的关系进行了研究。磷酸钙（CaP）或磷酸镁铵（MAP）结石在女性中更常见，而一水草酸钙（COM）、二水草酸钙（COD）或尿酸（UA）结石在男性中更常见。老年人与UA结石的风险增加和COD，CaP或胱氨酸结石的风险降低相关。此外，从2002年到2014年，COD和MAP结石的频率增加，而CaP，UA和胱氨酸结石的趋势下降。然而，日历月（季节）是没有显着相关的差异组成。ConclusionThis study provides the present distribution of urolithiasis compositions in China.从2002年到2014年，年龄和性别与结石成分显著相关，而日历月份则无关。
BackgroundThe incidence and prevalence of urinary stone are increasing throughout the world. Compared to the past, recent demographics of patient with urolithiasis compositions are strikingly different. Furthermore, recent clinical studies implied that seasonal cyclicity might influence the distribution of stone composition.MethodsWe sought to determine the trends in pathogenesis of urolithiasis based on urinary stone analyses. Between 2002 and 2014, a total of 2,383 eligible urinary stone samples from different patients were collected in our center. Infrared spectroscopy was used for urinary calculi analysis. A logistic regression analysis was used to investigate the relationship between urinary calculi composition and calendar month (season), gender, and age in north China during the past 13 years.ResultsCalcium-containing calculi were the most frequent with an overall incidence of 84.1%. Calcium phosphate (CaP) or magnesium ammonium phosphate (MAP) stones were more frequent in females, while monohydrate calcium oxalate (COM), dihydrate calcium oxalate (COD), or uric acid (UA) stones were more common in males. Older individuals were associated with an increased risk of UA stones and a decreased risk of COD, CaP, or cystine stones. Additionally, from 2002 to 2014, the frequency of COD and MAP stone increased, whereas the trend of CaP, UA and cystine stones decreased. However, calendar month (season) was not significantly associated with differences in composition.ConclusionThis study provides the present distribution of urolithiasis compositions in China. From 2002 to 2014, age and gender were significantly associated with stone composition, whereas calendar month was not.