Using chronic recordings from a closed-loop neurostimulation system to capture seizures across multiple thalamic nuclei.

Using chronic recordings from a closed-loop neurostimulation system to capture seizures across multiple thalamic nuclei.
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DOI:
10.1002/acn3.51701
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发表时间:
2023-01
影响因子:
5.3
通讯作者:
Rolston, John D.
Rolston, John D.
中科院分区:
医学2区
文献类型:
--
作者:
Kundu, Bornali;Arain, Amir;Davis, Tyler;Charlebois, Chantel M.;Rolston, John D.

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我们报告了一名单侧弥漫性额颞叶癫痫患者的病例,我们在该患者中植入了反应性神经刺激系统,其导线跨越丘脑前核和中央正中核。在慢性记录过程中,中心正中核的发作活动始终先于前核,这意味着涉及丘脑的暂时组织的癫痫网络。通过刺激,患者的局灶性意识障碍癫痫发作和继发性全身性癫痫发作得到缓解。该报告描述了半球内多个丘脑核团的癫痫发作活动的长期记录,并证明了多个丘脑核团的闭环神经刺激控制癫痫发作的潜在功效。
We report the case of a patient with unilateral diffuse frontotemporal epilepsy in whom we implanted a responsive neurostimulation system with leads spanning the anterior and centromedian nucleus of the thalamus. During chronic recording, ictal activity in the centromedian nucleus consistently preceded the anterior nucleus, implying a temporally organized seizure network involving the thalamus. With stimulation, the patient had resolution of focal impaired awareness seizures and secondarily generalized seizures. This report describes chronic recordings of seizure activity from multiple thalamic nuclei within a hemisphere and demonstrates the potential efficacy of closed‐loop neurostimulation of multiple thalamic nuclei to control seizures.
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