Mechanisms of GABAB Receptor Exocytosis, Endocytosis, and Degradation
Mechanisms of GABAB Receptor Exocytosis, Endocytosis, and Degradation
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DOI：
10.1016/s1054-3589(10)58004-9
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发表时间：
2010-01-01
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影响因子：
--
通讯作者：
Benke, Dietmar
中科院分区：
文献类型：
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作者：
Benke, Dietmar
GABA（B）受体属于G蛋白偶联受体家族，其介导中枢神经系统中的缓慢抑制性神经传递。它们是多种神经系统疾病的有希望的药物靶点，并在调节突触可塑性方面发挥重要作用。信号强度严重依赖于细胞表面受体的可用性。几种不同的高度调节的运输机制确保质膜中存在足够数量的受体。新合成的受体从内质网通过高尔基体到细胞表面的胞吐速率以及它们的内吞和降解速率决定了受体在细胞表面的保留时间。本章重点介绍了最近出现的GABA（B）受体胞吐，胞吞，回收和降解的机制。
GABA(B) receptors belong to the family of G-protein-coupled receptors, which mediate slow inhibitory neurotransmission in the central nervous system. They are promising drug targets for a variety of neurological disorders and play important functions in regulating synaptic plasticity. Signaling strength is critically dependent on the availability of the receptors at the cell surface. Several distinct highly regulated trafficking mechanisms ensure the presence of adequate receptor numbers in the plasma membrane. The rate of exocytosis of newly synthesized receptors from the endoplasmic reticulum via the Golgi apparatus to the cell surface as well as the rates of their endocytosis and degradation determines the retention time of receptors at the cell surface. This chapter focuses on the recently emerged mechanisms of GABA(B) receptor exocytosis, endocytosis, recycling, and degradation.