Blood flow responses to intra-arterial acetylcholine in man: effects of basal flow and conduit vessel length.
Blood flow responses to intra-arterial acetylcholine in man: effects of basal flow and conduit vessel length.
复制标题
人体对动脉内乙酰胆碱的血流反应：基础流量和导管长度的影响。
DOI：
10.1042/cs0870045
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发表时间：
1994
期刊：
影响因子：
6
通讯作者：
J. Ritter
中科院分区：
文献类型：
--
作者：
P. Chowienczyk;J. Cockcroft;J. Ritter
1. 乙酰胆碱使人的抵抗血管松弛，并从内皮细胞释放一氧化氮和其他因子。比较对乙酰胆碱的反应与对内皮非依赖性血管扩张剂（如硝普塞）的反应形成了所谓的内皮功能乙酰胆碱试验的基础。然而，当该试验通过动脉内输注在体内应用时，乙酰胆碱的代谢不稳定性可能导致对这些药物的不同反应，这是由于解剖上的差异，而不是功能上的差异。2. 采用静脉闭塞容积描记术，对30名健康受试者肱动脉输注乙酰胆碱（41和83 nmol/min）和硝普钠（11和38 nmol/min）后的血管舒张反应进行了测量。3. 与硝普钠相比，乙酰胆碱对静息血流量（P < 0.05）和前臂长度（P < 0.05）的依赖性更大（用简单血流量模型预测结果）。4. 修正前臂长度消除了男性和女性对乙酰胆碱反应之间59%的明显差异。导管几何形状和静息血流量影响内皮功能乙酰胆碱试验。
1. Acetylcholine relaxes human resistance vessels and releases nitric oxide and other factors from the endothelium. Comparison of responses to acetylcholine with those to an endothelium-independent vasodilator (such as nitroprusside) forms the basis of the so-called acetylcholine test of endothelial function. However, when this test is applied in vivo by intraarterial infusion, the metabolic instability of acetylcholine may result in differential responses to these drugs arising from anatomical rather than functional differences. 2. Vasodilator responses to brachial artery infusions of acetylcholine (41 and 83 nmol/min) and sodium nitroprusside (11 and 38 nmol/min) were measured in 30 healthy human subjects using venous occlusion plethysmography. 3. Responses to acetylcholine showed a greater dependence on resting blood flow (P < 0.05) and on forearm length (P < 0.05) than those to sodium nitroprusside (results predicted by a simple blood flow model). 4. Correction for forearm length abolished an apparent difference of 59% between responses to acetylcholine in men and women. Conduit vessel geometry and resting blood flow influence the acetylcholine test of endothelial function.