A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women
A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women
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DOI：
10.1139/h11-115
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发表时间：
2011-12-01
影响因子：
3.4
通讯作者：
Lamarche, Benoit
中科院分区：
文献类型：
--
作者：
Paradis, Marie-Eve;Couture, Patrick;Lamarche, Benoit
这项研究检查了褐藻对男性和女性负荷后血糖和胰岛素浓度的影响。这项双盲、随机、安慰剂对照交叉研究招募了23名年龄在19-59岁的参与者（11名男性，12名女性）。供试品由市售的褐藻（Ascophyllum nodosum和Fucus vesiculosus）混合物组成，已知对α-淀粉酶和α-葡糖苷酶活性具有抑制作用（InSea（2））。每次在食用50 g来自面包的碳水化合物之前30分钟食用2粒250 mg海藻胶囊和2粒安慰剂胶囊。在预先确定的时间点，测量碳水化合物摄入后3小时内的血糖和胰岛素浓度。两种治疗间隔1周洗脱期。使用重复测量的混合模型分析数据。与安慰剂相比，海藻的消费与胰岛素增量曲线下面积减少12.1%（p = 0.04，基线校正）和Cederholm胰岛素敏感性指数增加7.9%（p < 0.05）相关。单次摄入500 mg褐藻对葡萄糖反应没有显著影响（p = 0.24，根据基线调整）。男性和女性的葡萄糖和胰岛素反应相似。食用海藻胶囊与任何不良事件无关。这些数据表明，褐藻可能会改变胰岛素的稳态响应碳水化合物的摄入。
This study examined the impact of brown seaweed on post-load plasma glucose and insulin concentrations in men and women. Twenty-three participants (11 men, 12 women) aged 19-59 years were recruited in this double-blind, randomized, placebo-controlled crossover study. The test product consisted of a commercially available blend of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) with known inhibitory action on alpha-amylase and alpha-glucosidase activities (InSea(2)). Two 250 mg seaweed capsules and 2 placebo capsules were consumed on each occasion 30 min prior to the consumption of 50 g of carbohydrates from bread. Plasma glucose and insulin concentrations were measured over a period of 3 h postcarbohydrate ingestion at predetermined time points. Both treatments were separated by a 1-week washout period. Data were analysed using mixed models for repeated measures. Compared with placebo, consumption of seaweed was associated with a 12.1% reduction in the insulin incremental area under the curve (p = 0.04, adjusted for baseline) and a 7.9% increase in the Cederholm index of insulin sensitivity (p < 0.05). The single ingestion of 500 mg of brown seaweed had no significant effect on the glucose response (p = 0.24, adjusted for baseline). Glucose and insulin responses were similar between men and women. Consumption of the seaweed capsules was not associated with any adverse event. These data suggest that brown seaweed may alter the insulin homeostasis in response to carbohydrate ingestion.