Visceral and central abdominal fat and anthropometry in relation to diabetes in Asian Indians
Visceral and central abdominal fat and anthropometry in relation to diabetes in Asian Indians
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DOI：
10.2337/diacare.27.12.2948
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发表时间：
2004-12-01
期刊：
影响因子：
16.2
通讯作者：
Mohan, V
中科院分区：
文献类型：
--
作者：
Anjana, M;Sandeep, S;Mohan, V
目的：本研究的目的是利用计算机断层扫描（CT）、双能x线吸收仪（DEXA）和人体测量学检查亚洲城市印度人体内脂肪分布与2型糖尿病的关系。研究设计和方法：这是一项病例对照研究，82名2型糖尿病患者和82名年龄和性别匹配的非糖尿病受试者来自金奈城乡流行病学研究，这是一项正在印度南部进行的流行病学研究。使用CT测量内脏、皮下和腹部总脂肪，使用DEXA测量腹部中央和全身脂肪。人体测量包括BMI、腰围、矢状腹径（SAD）和腰臀比。结果：内脏脂肪和腹部中央脂肪之间存在很强的相关性（P < 0.0001）， K分析显示内脏脂肪和腹部中央脂肪之间存在相当好的一致性（K = 0.44, P < 0.0001）。糖尿病患者的内脏脂肪（P = 0.005）和腹部脂肪（P = 0.011）明显高于非糖尿病患者。腰围和SAD与糖尿病和非糖尿病受试者的内脏脂肪（P < 0.01）和腹部脂肪（P < 0.0001）有很强的相关性。Logistic回归分析显示，即使在调整年龄和性别后，内脏脂肪（比值比[OR] 1.011, P = 0.004）和腹部脂肪（比值比[OR] 1.001, P = 0.013）与糖尿病相关。结论：内脏脂肪和腹部中央脂肪与2型糖尿病密切相关。在糖尿病和非糖尿病的亚洲城市印度人中，这两种测量结果相互之间以及与腰围和SAD相关良好。
OBJECTIVE - The objective of the study was to examine body fat distribution using computed tomography (CT), dual-energy X-ray absorptiometry (DEXA), and anthropometry in relation to type 2 diabetes in urban Asian Indians.RESEARCH DESIGN AND METHODS - This is a case-control study of 82 type 2 diabetic and 82 age- and sex-matched nondiabetic subjects from the Chennai Urban Rural Epidemiology Study, an ongoing epidemiological study in southern India. Visceral, subcutaneous, and total abdominal fat were measured using CT, while DEXA was used to measure central abdominal and total body fat. Anthropometric measures included BMI, waist circumference, sagittal abdominal diameter (SAD), and waist-to-hip ratio.RESULTS - Visceral and central abdominal fat showed a strong correlation with each other (P < 0.0001), and K analysis revealed a fairly good agreement between tertiles of visceral and central abdominal fat (K = 0.44, P < 0.0001). Diabetic subjects had significantly higher visceral (P = 0.005) and central abdominal (P = 0.011) fat compared with nondiabetic subjects. Waist circumference and SAD showed a strong correlation with visceral (P < 0.01) and central abdominal (P < 0.0001) fat in both diabetic and nondiabetic subjects. Logistic regression analysis revealed visceral (odds ratio [OR] 1.011, P = 0.004) and central abdominal (OR 1.001, P 0.013) fat to be associated with diabetes, even after adjusting for age and sex.CONCLUSIONS - Visceral and central abdominal fat showed a strong association with type 2 diabetes. Both measures correlated well with each other and with waist circumference and SAD in diabetic and nondiabetic urban Asian Indians.