Nrf2: a potential target for new therapeutics in liver disease.

Nrf2: a potential target for new therapeutics in liver disease.
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DOI:
10.1038/clpt.2012.110
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发表时间:
2012-09
影响因子:
6.7
通讯作者:
--
中科院分区:
医学2区
文献类型:
--
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核红细胞2相关因子2(Nrf 2)是一种氧化应激介导的转录因子,具有多种下游靶点,旨在细胞保护。nrf 2最近被认为是治疗肝脏疾病的新靶点。在这里,我们专注于最常见的肝脏疾病-非酒精性脂肪性肝病/脂肪性肝炎,酒精性肝病和药物性肝损伤-并强调在这些条件的发展中,Nrf 2的激活可能会缓解疾病进展。
Nuclear erythroid 2–related factor 2 (Nrf2) is an oxidative stress–mediated transcription factor with a variety of downstream targets aimed at cytoprotection. Nrf2 has recently been implicated as a new therapeutic target for the treatment of liver disease. Here, we focus on the most common liver diseases—nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease, and drug-induced liver injury—and highlight areas in the development of these conditions where activation of Nrf2 may alleviate disease progression.
DOI: 10.1159/000014377
发表时间: 1999-01-01
期刊: BLOOD PURIFICATION
影响因子: 3
作者:
Haugen, E;Nath, KA
通讯作者: Nath, KA
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