Incidence of invasive cancers following squamous cell skin cancer.
Incidence of invasive cancers following squamous cell skin cancer.
复制标题
鳞状细胞皮肤癌后侵袭性癌症的发病率。
作者：
F. Levi;L. Randimbison;C. Vecchia;G. Erler;V. Te
作者描述了瑞士沃州和纳沙泰尔州癌症登记处1974年至1994年诊断的4，639例鳞状细胞皮肤癌（SCC）中新发原发性癌症的发病率（总风险人年= 23，152）。总体而言，观察到729例异时性癌症，而预期为527.6例，相当于标准化发病率比（SIR）为1.4（95%置信区间（CI）1.3-1.5）。然而，在排除皮肤癌后，观察到384例第二原发性肿瘤，而预期为397.2例（SIR = 1.0）。观察到唇癌（SIR = 3.1）和肺癌（SIR = 1.3）、基底细胞癌（SIR = 4.3）和黑色素瘤性皮肤癌（SIR = 3.3）以及非霍奇金淋巴瘤（SIR = 1.7）过度。唾液腺癌的发病率升高，（SIR = 4.3）和霍奇金病（SIR = 2.7），以及65岁以下的肺癌（SIR = 1.6），乳房（SIR = 1.5）和前列腺（SIR = 1.8），霍奇金病（SIR = 15.8），以及除皮肤外的所有肿瘤（SIR = 1.2; 95% CI 1.0-1.5）。15年后，基底细胞皮肤癌的累积风险达到17%。作者认为，SCC后皮肤基底细胞癌和黑色素瘤以及淋巴瘤的过度可能归因于共同的表型特征和暴露于紫外线辐射。肺癌发病率的升高表明烟草是鳞状细胞皮肤癌的一个原因。
The authors describe the incidence of new primary cancers among 4,639 cases of squamous cell skin cancer (SCC) diagnosed between 1974 and 1994 in the cancer registries of the Swiss cantons of Vaud and Neuchâtel (total person-years at risk = 23,152). Overall, 729 metachronous cancers were observed versus 527.6 expected, corresponding to a standardized incidence ratio (SIR) of 1.4 (95% confidence interval (CI) 1.3-1.5). After exclusion of skin cancers, however, 384 second primary neoplasms were observed versus 397.2 expected (SIR = 1.0). Excesses were observed for cancers of the lip (SIR = 3.1) and lung (SIR = 1.3), for basal cell (SIR = 4.3) and melanomatous skin cancers (SIR = 3.3), and non-Hodgkin's lymphomas (SIR = 1.7). Rates were elevated for cancers of the salivary glands (SIR = 4.3) and for Hodgkin's disease (SIR = 2.7), and, below age 65 years, for cancers of the lung (SIR = 1.6), breast (SIR = 1.5), and prostate (SIR = 1.8), for Hodgkin's disease (SIR = 15.8), as well as for all neoplasms except skin (SIR = 1.2; 95% CI 1.0-1.5). The cumulative risk of basal cell skin cancer reached 17% after 15 years. The authors believe that the excesses for basal cell carcinomas and melanomas of the skin following SCC, and possibly of lymphomas, were likely attributable to common phenotypic characteristics and exposure to UV radiation. The elevated rates of lung cancer are suggestive for a role of tobacco as a cause of squamous cell skin cancer.