Diffusive drug delivery in the brain extracellular space from a cellular scale microtube.
Diffusive drug delivery in the brain extracellular space from a cellular scale microtube.
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DOI：
10.1557/s43579-022-00247-9
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发表时间：
2022
影响因子：
1.9
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中科院分区：
文献类型：
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最先进的神经系统疾病全身治疗的有效性不仅受到难以穿过血脑屏障的阻碍，而且还受到脱靶药物相互作用的阻碍。在这项研究中，一种新的U形微管局部输注药物直接进入脑细胞外空间，并依赖于扩散作为运输机制的传递方法进行了模拟。流速，药物性质和设备的几何形状的影响进行了研究。预计这些发现将加速开发和应用药物输送和材料研究的进展。在线版本包含补充材料，可通过10.1557/s43579-022-00247-9获得。
The effectiveness of state-of-the-art systemic treatments for neurological disorders is hampered not only by the difficulty in crossing the blood brain barrier but also off-target drug interactions. In this study, a delivery method is simulated for a novel U-shaped microtube locally infusing drugs directly into the extracellular space of the brain and relying on diffusion as a transport mechanism. The influence of flow rate, drug properties and device geometry are investigated. It is anticipated that these findings will accelerate progress on both developmental and applied drug delivery and materials research. The online version contains supplementary material available at 10.1557/s43579-022-00247-9.