Temporal changes in calcium-binding proteins in the medial geniculate nucleus of the monkey Sapajus apella
Temporal changes in calcium-binding proteins in the medial geniculate nucleus of the monkey Sapajus apella
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DOI：
10.1016/j.jchemneu.2015.07.005
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发表时间：
2015-10-01
影响因子：
2.8
通讯作者：
Pinato, Luciana
中科院分区：
文献类型：
--
作者：
Campos, Leila M. G.;Osorio, Elaine C.;Pinato, Luciana
内侧膝状体复合体的细分可以区分基于钙结合蛋白的免疫染色和每个细分内的神经元的属性。在这个和其他中央听觉区的神经化学变化的可能性是重要的方面，以了解的基础上，有助于由环境周期或动物的活动和休息周期确定的功能变化。本研究调查，第一次，白天/晚上的差异的量的小白蛋白，calretinin和calbindin含神经元在丘脑听觉中心的非人灵长类动物，Sapajus apella。PV-IR、CB-IR和CR-IR神经元在内侧膝状体各亚群中的分布模式不同。此外，大量的CB和CR-IR神经元在白天发现，而PV-IR是主要在夜间。我们的结论是，除了化学异质性的内侧膝状体核相对于钙结合蛋白的表达，表达也有所不同，相对于光明和黑暗的时期，这可能是重要的一个可能的中央听觉区的功能适应环境的变化，从而确保生存和发展的几个相关功能。(C)2015 Elsevier B. V.版权所有。
The subdivisions of the medial geniculate complex can be distinguished based on the immunostaining of calcium-binding proteins and by the properties of the neurons within each subdivision. The possibility of changes in neurochemistry in this and other central auditory areas are important aspects to understand the basis that contributing to functional variations determined by environmental cycles or the animal's cycles of activity and rest. This study investigated, for the first time, day/night differences in the amounts of parvalbumin-, calretinin- and calbindin-containing neurons in the thalamic auditory center of a nonhuman primate, Sapajus apella. The immunoreactivity of the PV-IR, CB-IR and CR-IR neurons demonstrated different distribution patterns among the subdivisions of the medial geniculate. Moreover, a high number of CB- and CR-IR neurons were found during day, whereas PV-IR was predominant at night. We conclude that in addition to the chemical heterogeneity of the medial geniculate nucleus with respect to the expression of calcium-binding proteins, expression also varied relative to periods of light and darkness, which may be important for a possible functional adaptation of central auditory areas to environmental changes and thus ensure the survival and development of several related functions. (C) 2015 Elsevier B.V. All rights reserved.