Competitive Disinhibition Mediates Behavioral Choice and Sequences in Drosophila
Competitive Disinhibition Mediates Behavioral Choice and Sequences in Drosophila
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DOI：
10.1016/j.cell.2016.09.009
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发表时间：
2016-10-20
期刊：
影响因子：
64.5
通讯作者：
Zlatic, Marta
中科院分区：
文献类型：
--
作者：
Jovanic, Tihana;Schneider-Mizell, Casey Martin;Zlatic, Marta
即使是简单的感官刺激也可以引发独特的先天行为和序列。在感觉运动决策过程中，促进不同行为的神经元之间的竞争性相互作用必须确保一种行为的选择和维持，同时抑制其他行为。这些竞争性相互作用的电路实现仍然是一个悬而未决的问题。通过结合抑制性中间神经元网络的全面电子显微镜重建、建模、电生理学和行为研究，我们确定了有助于果蝇幼虫感觉运动决定惊吓、探索或执行两者响应机械感觉刺激的序列的电路机制。总之，这些研究表明，在感觉处理的早期，(1) 相互连接的前馈抑制性中间神经元实现行为选择，(2) 局部反馈去抑制提供巩固和维持所选行为的正反馈，(3) 横向去抑制促进序列转换。这些互连电路图案的组合可以实现行为选择和将行为串行组织成序列。
Even a simple sensory stimulus can elicit distinct innate behaviors and sequences. During sensorimotor decisions, competitive interactions among neurons that promote distinct behaviors must ensure the selection and maintenance of one behavior, while suppressing others. The circuit implementation of these competitive interactions is still an open question. By combining comprehensive electron microscopy reconstruction of inhibitory interneuron networks, modeling, electrophysiology, and behavioral studies, we determined the circuit mechanisms that contribute to the Drosophila larval sensorimotor decision to startle, explore, or performa sequence of the two in response to a mechanosensory stimulus. Together, these studies reveal that, early in sensory processing, (1) reciprocally connected feedforward inhibitory interneurons implement behavioral choice, (2) local feedback disinhibition provides positive feedback that consolidates and maintains the chosen behavior, and (3) lateral disinhibition promotes sequence transitions. The combination of these interconnected circuit motifs can implement both behavior selection and the serial organization of behaviors into a sequence.