Effect of individual l-amino acids on gastric acid secretion and serum gastrin and pancreatic polypeptide release in humans.
Effect of individual l-amino acids on gastric acid secretion and serum gastrin and pancreatic polypeptide release in humans.
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DOI：
10.1016/0016-5085(82)90187-1
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发表时间：
1982-07
期刊：
影响因子：
29.4
通讯作者：
Ian L. Taylors;Ian L. Taylors;William J. Byrne;William J. Byrne;Dennis L. Christie;Dennis L. Christie;Marvin E. Ament;Marvin E. Ament;J H Walsh;J H Walsh
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文献类型：
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作者：
Ian L. Taylors;Ian L. Taylors;William J. Byrne;William J. Byrne;Dennis L. Christie;Dennis L. Christie;Marvin E. Ament;Marvin E. Ament;J H Walsh;J H Walsh
单独灌胃所有氨基酸，以确定刺激胃酸分泌和胃泌素和胰多肽释放的可能差异。苯丙氨酸和色氨酸对胃酸分泌、胰腺多肽和胃泌素释放的刺激作用明显强于其他任何一种氨基酸。苏氨酸对胰腺多肽和丝氨酸对酸分泌的反应较小，但意义重大。我们得出结论，混合氨基酸溶液的促酸作用主要是由芳香氨基酸、苯丙氨酸和色氨酸来解释的，它们也是胃泌素和胰腺多肽释放的最有效的刺激物。这些研究表明，氨基酸混合物的特定组成决定了这种混合物对胃分泌的净影响，以及对胃窦激素胃泌素和胰腺激素胰多肽释放的净影响。
IndividualL-amino acids were instilled intragastrically to determine possible differences in stimulation of gastric acid secretion and gastrin and pancreatic polypeptide release. Phenylalanine and tryptophan were significantly more potent stimulants of gastric acid secretion and of pancreatic polypeptide and gastrin release than any of the other amino acids tested. Smaller, but significant, responses were obtained with threonine for pancreatic polypeptide and with serine for acid secretion. We conclude that a major part of the acid-stimulating action of mixed amino acid solution can be explained by the aromatic amino acids, phenylalanine and tryptophan, which are also the most potent stimulants of gastrin and pancreatic polypeptide release. These studies suggest that the specific composition of amino acid mixtures determines the net effects of such mixtures on gastric secretion, and on release of both the antral hormone gastrin and the pancreatic hormone, pancreatic polypeptide.