Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease
Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease
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DOI：
10.1016/s0165-5728(97)00227-0
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发表时间：
1998-03-15
影响因子：
3.3
通讯作者：
Pettit, DAD
中科院分区：
文献类型：
--
作者：
Cabral, GA;Pettit, DAD
大麻，大麻，elevens各种影响实验动物和人类。Delta-9-tetrahydrocannabinol（THC）是大麻中主要的精神活性成分。这种物质也被证明是免疫抑制剂，并降低宿主对细菌、原生动物和病毒感染的抵抗力。巨噬细胞、T淋巴细胞和自然杀伤细胞似乎是THC免疫抑制作用的主要靶点。目前还没有将大麻的使用与人类感染易感性增加直接联系起来的可靠数据。然而，累积的报告表明，THC在体外和各种实验动物中改变了对感染的抵抗力，这支持了人类发生类似作用的假设。(C)1998年Elsevier Science B.V.
Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans. (C) 1998 Elsevier Science B.V.