Thrombopoietic status of patients on haemodialysis.
Thrombopoietic status of patients on haemodialysis.
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血液透析患者的血小板生成状态。
DOI：
10.1111/bjh.13918
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发表时间：
2016
影响因子：
6.5
通讯作者：
Sarac,Erdal
中科院分区：
文献类型：
--
作者：
Bat,Taha;Bat,BetulE;El-Moghraby,Ahmed;Patel,Samir;Feng,Xingmin;Dunbar,CynthiaE;Sarac,Erdal
血小板减少症是一种潜在的透析相关治疗并发症。生物相容性透析膜的发展减少了血小板减少症的发生。我们通过测量血液透析患者血液中的血小板生成素水平和绝对未成熟血小板数量（AIPN）来研究血液透析患者的血小板生成是否受损。在45例特征明确的血液透析患者中，从透析前和透析后的透析管中收集样本。血液透析后血栓生成素水平和AIPN增加，尽管血小板计数没有变化。观察到血液透析后未成熟血小板从骨髓中释放的增加表明补体活化可能继发于血液成分和透析膜之间的相互作用。
Thrombocytopenia is a potential dialysis‐related treatment complication. Developments in bio‐compatible dialyser membranes have decreased the occurrence of thrombocytopenia. We investigated whether thrombopoiesis is impaired in haemodialysis patients by measuring the thrombopoietin level and absolute immature platelet number (AIPN) in the blood of patients undergoing haemodialysis. Samples were collected from the dialysis tubing pre‐ and post‐ haemodialysis in a cohort of 45 well‐characterized haemodialysis patients. Thrombopoietin levels and AIPN increased following haemodialysis, despite no change in platelet count. Observed increase in release of immature platelets from the bone marrow following haemodialysis indicates possible complement activation secondary to interaction between blood constituents and the dialysis membrane.