Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients.
Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients.
复制标题
日本2型糖尿病患者的醛糖还原酶基因与糖尿病性大型神经病有关。
DOI：
10.1111/j.1464-5491.2006.01946.x
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发表时间：
2006-08
期刊：
影响因子：
--
通讯作者：
Nakamura J
中科院分区：
文献类型：
--
作者：
Watarai A;Nakashima E;Hamada Y;Watanabe G;Naruse K;Miwa K;Kobayashi Y;Kamiya H;Nakae M;Hamajima N;Sekido Y;Niwa T;Oiso Y;Nakamura J
醛糖还原酶（AR）基因是多元醇途径的限速酶，已被研究为决定糖尿病微血管病变易感性的候选基因。然而，AR基因与糖尿病大血管病变的关联尚未研究。因此，本研究旨在确定AR的遗传变异是否可能决定糖尿病大血管病变的易感性。共有378例2型糖尿病患者入组本研究。启动子区（C-106 T）的单核苷酸多态性进行基因分型，并通过ELISA测定红细胞AR蛋白含量。缺血性心脏病组与非缺血性心脏病组的基因型和等位基因分布差异无统计学意义，但脑卒中组CT + TT基因型和T等位基因频率显著增高（P = 0.019和P = 0.012）。与CC基因型相比，CT和TT基因型患者红细胞AR蛋白含量增加。在多变量logistic回归模型中调整了年龄、糖尿病病程、体重指数、收缩压、HbA 1c、血清肌酐、甘油三酯和总胆固醇后，AR基因型与卒中之间的关联仍然显著。我们的研究结果表明，AR基因的CT或TT基因型可能是2型糖尿病患者中风易感性的遗传标记。这一观察结果可能有助于制定预防2型糖尿病患者卒中的策略。
The aldose reductase (AR) gene, a rate-limiting enzyme of the polyol pathway, has been investigated as a candidate gene in determining susceptibility to diabetic microangiopathy. However, the association of the AR gene with diabetic macroangiopathy has not been investigated. Therefore, the present study was conducted to determine whether genetic variations of AR may determine susceptibility to diabetic macroangiopathy. There were 378 Type 2 diabetic patients enrolled in this study. A single nucleotide polymorphism in the promoter region (C-106T) was genotyped and the AR protein content of erythrocytes measured by ELISA. There were no significant differences in genotypic or allelic distribution in patients with or without ischaemic heart diseases, but there was a significant increase in the frequency of the CT + TT genotype and T allele in patients with stroke (P = 0.019 and P = 0.012). The erythrocyte AR protein content was increased in patients with the CT and TT genotype compared with those with the CC genotype. After adjustment for age, duration of diabetes, body mass index, systolic blood pressure, HbA1c, and serum creatinine, triglycerides, and total cholesterol in multivariate logistic-regression models, the association between this AR genotype and stroke remained significant. Our results suggest that the CT or TT genotype of the AR gene might be a genetic marker of susceptibility to stroke in Type 2 diabetic patients. This observation might contribute to the development of strategies for the prevention of stroke in Type 2 diabetic patients.
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影响因子：
16.2
作者：
Wang, Y;Ng, MCY;Chan, JCN
通讯作者：
Chan, JCN
影响因子：
3.5
作者：
Moczulski, DK;Scott, L;Krolewski, AS
通讯作者：
Krolewski, AS
影响因子：
4.8
作者：
Ramana, KV;Chandra, D;Srivastava, SK
通讯作者：
Srivastava, SK
影响因子：
3.5
作者：
Neamat-Allah, M;Feeney, SA;Cox, A
通讯作者：
Cox, A
影响因子：
--
作者：
Gosek, K;Moczulski, D;Zukowska-Szczechowska, E
通讯作者：
Zukowska-Szczechowska, E