Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
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DOI：
10.1126/science.1080613
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发表时间：
2003-03-28
期刊：
影响因子：
56.9
通讯作者：
Fraser, CM
中科院分区：
文献类型：
--
作者：
Paulsen, IT;Banerjei, L;Fraser, CM
粪肠球菌V583是一株对万古霉素耐药的临床分离株，其全基因组序列显示，超过四分之一的基因组由可能的可移动DNA或外源DNA组成。预测的可移动元件之一是先前未知的万古霉素抗性结合转座子。共鉴定出三个质粒，包括两个信息素敏感结合质粒，一个编码以前未被描述的信息素抑制物。在肠球菌中迅速获得和传播耐药性，可能是因为有明显的结合可移动成分的倾向。
The complete genome sequence of Enterococcusfaecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.