Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting.
Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting.
复制标题
DOI：
10.1080/15459624.2015.1060324
复制
发表时间：
2015
影响因子：
2
通讯作者：
Yucesoy B
中科院分区：
文献类型：
--
作者：
DeBord DG;Burgoon L;Edwards SW;Haber LT;Kanitz MH;Kuempel E;Thomas RS;Yucesoy B
在最近的一份国家研究理事会文件中，介绍了新的风险评估战略，以实现更准确和更快的评估。（）该报告建议，通过更多地使用生物监测来评价个体反应，可以改进剂量-反应估计。特定生物标志物的鉴定可能有助于诊断或风险预测，因为它们有可能改善暴露评估。本文讨论了系统生物学，生物标志物的影响，和计算毒理学方法及其相关的职业接触限值设置过程。系统生物学方法评估生物过程的整合以及化学品或其他危害对这些过程的破坏如何影响疾病结果。这种方法可以提供用于描述反应或毒性作用模式的信息，并可能有助于确定低不利影响和无不利影响水平。效应生物标志物是在生物系统中测量的变化，被认为是临床前性质的。允许在单个分析中同时测量大分子家族如DNA、RNA和蛋白质的计算方法和实验组学方法的进展使得这些系统方法对于广泛应用是可行的。从组学方法的风险评估的信息的效用已显示出希望，并可以提供信息的行动方式和剂量-反应关系。随着这些技术的发展，内部剂量和反应生物标志物的估计将是这些新技术应用于风险评估策略的关键测试。虽然已经进行了概念验证研究，证明了这些方法的价值，但在常规使用这些方法之前，仍然需要克服标准化和统一方面的挑战。
In a recent National Research Council document, new strategies for risk assessment were described to enable more accurate and quicker assessments.( ) This report suggested that evaluating individual responses through increased use of bio-monitoring could improve dose-response estimations. Identi-fication of specific biomarkers may be useful for diagnostics or risk prediction as they have the potential to improve exposure assessments. This paper discusses systems biology, biomarkers of effect, and computational toxicology approaches and their relevance to the occupational exposure limit setting process. The systems biology approach evaluates the integration of biological processes and how disruption of these processes by chemicals or other hazards affects disease outcomes. This type of approach could provide information used in delineating the mode of action of the response or toxicity, and may be useful to define the low adverse and no adverse effect levels. Biomarkers of effect are changes measured in biological systems and are considered to be preclinical in nature. Advances in computational methods and experimental -omics methods that allow the simultaneous measurement of families of macromolecules such as DNA, RNA, and proteins in a single analysis have made these systems approaches feasible for broad application. The utility of the information for risk assessments from -omics approaches has shown promise and can provide information on mode of action and dose-response relationships. As these techniques evolve, estimation of internal dose and response biomarkers will be a critical test of these new technologies for application in risk assessment strategies. While proof of concept studies have been conducted that provide evidence of their value, challenges with standardization and harmonization still need to be overcome before these methods are used routinely.