Studies on the mechanism by which phosphate infusion lowers serum calcium concentration
Studies on the mechanism by which phosphate infusion lowers serum calcium concentration
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DOI：
10.1172/jci105493
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发表时间：
1966-01-01
期刊：
影响因子：
15.9
通讯作者：
LENNON, EDWARD J.
中科院分区：
文献类型：
--
作者：
HEBERT, LEE A.;LEMANN, JACOB;LENNON, EDWARD J.
中性，渗透Na-K磷酸盐，1-3 mM/kg，输注超过6小时。6例正常患者，3例甲状旁腺功能低下患者，4例甲状旁腺功能亢进患者，3例癌症合并高钙血症患者，均持续饮食。P输注时血清[Ca]的变化。尿钙和粪钙排泄量也有所下降；因此Ca并没有从身体中消失。注射期间血清[Ca]的下降与平均[Ca x P]摩尔积呈线性相关：A Ca mM/L = 1。26-0。28 [Ca x P]摩尔x 10-6 （r = -0）85)。血清[Ca]和[P]的超滤率没有变化。因此，由于[Ca x P]摩尔积是衡量Ca- po4盐形成趋势的一个指标，P的注入似乎通过一种物理化学机制降低了[Ca]。[P]在24小时内恢复到控制水平。在所有科目中。相比之下，在高钙血症患者中，[Ca]在[Ca x P]拒绝控制后很长一段时间内仍保持降低。[Ca]在24小时内恢复控制。在正常受试者中。因此，[Ca]的恢复速度似乎与[Ca x P]无关，而涉及其他机制，可能是甲状旁腺激素，因为甲状旁腺功能低下的受试者中[Ca]的恢复也被延迟。摘要作者：作者
Neutral, is osmotic Na-K phosphate, 1-3 mM/kg, was infused over 6 hr. in 6 normal, 3 treated hypoparathyroid, and 4 hyperparathyroid subjects, and in 3 patients with cancer and hypercalcemia, all on constant diets. Serum [Ca] in all during P infusion. Urinary and fecal Ca excretion also fell; thus Ca was not lost from the body. The fall in serum [Ca] was linearly related to the mean [Ca x P] mole product during infusion: A Ca mM/L = 1. 26-0. 28 [Ca x P] mole x 10-6 (r = -0. 85). The percentages of serum [Ca] and [P] which were ultrafilterable did not change. Thus, since the [Ca x P] mole product is a measure of the tendency for Ca-PO4 salt formation, the infusion of P appears to lower [Ca] by a physico-chemical mechanism. [P] returned to control levels within 24 hr. in all subjects. By contrast, [Ca] remained reduced for days in the patients with hypercalcemia, long after [Ca x P] had declined to control. [Ca] returned to control within 24 hr. in the normal subjects. Thus the rate of restoration of [Ca] appears unrelated to [Ca x P] and involves some other mechanism, possibly parathyroid hormone, since recovery of [Ca] was also delayed in the hypoparathyroid subjects. || ABSTRACT AUTHORS: Authors