Ten-year incidence of age-related macular degeneration according to diabetic retinopathy classification among medicare beneficiaries.
Ten-year incidence of age-related macular degeneration according to diabetic retinopathy classification among medicare beneficiaries.
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DOI：
10.1097/iae.0b013e3182831248
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发表时间：
2013-05
期刊：
影响因子：
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通讯作者：
Sloan FA
中科院分区：
文献类型：
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作者：
Hahn P;Acquah K;Cousins SW;Lee PP;Sloan FA
比较美国 Medicare 受益人样本中 10 年来干性和湿性年龄相关性黄斑变性 (AMD) 的纵向发病率：无糖尿病 (no DM)；无视网膜病变的糖尿病 (DM)；非增殖性糖尿病视网膜病变（NPDR）；和增殖性糖尿病视网膜病变（PDR）。回顾性纵向队列分析 使用 Medicare 索赔数据，对 1995 年至 2005 年年龄 > 69 岁的新诊断 DM (n = 6,621)、NPDR (n = 1,307) 和 PDR (n = 327) 受益人的干性和湿性 AMD 的 10 年发病率进行了跟踪，并与每组的无糖尿病对照进行比较。控制协变量后，新诊断的 NPDR 与干性 AMD（风险比 (HR) 1.24；95% 置信区间 (CI) 1.08–1.43）和湿性 AMD（HR 1.68；95% CI：1.23–2.31）的事件诊断风险显着增加相关。新诊断的 PDR 仅与湿性 AMD 风险显着增加相关（HR 2.15；95% CI：1.07-4.33）。没有视网膜病变的糖尿病不会影响干性或湿性 AMD 的风险。与 NPDR 相比，PDR 的湿性 AMD 风险没有差异。与没有糖尿病或糖尿病视网膜病变的老年人相比，患有非增殖性或增殖性糖尿病视网膜病变的老年人患 AMD 的风险可能更高。
To compare the longitudinal incidence over 10 years of dry and wet age-related macular degeneration (AMD) in a U.S. sample of Medicare beneficiaries with: no diabetes mellitus (no DM); diabetes mellitus without retinopathy (DM); non-proliferative diabetic retinopathy (NPDR); and proliferative diabetic retinopathy (PDR). Retrospective, longitudinal cohort analysis Using Medicare claims data, the 10-year incidence of dry and wet AMD was followed from 1995–2005 in beneficiaries aged >69 years with newly diagnosed DM (n=6,621), NPDR (n=1,307), and PDR (n=327) compared with each other and matched controls without diabetes for each group. After controlling for covariates, newly diagnosed NPDR was associated with significantly increased risk of incident diagnosis of dry AMD (hazard ratio (HR) 1.24; 95% confidence interval (CI) 1.08–1.43) and wet AMD (HR 1.68; 95% CI: 1.23–2.31). Newly diagnosed PDR was associated with significantly increased risk of wet AMD only (HR 2.15; 95% CI: 1.07–4.33). Diabetes without retinopathy did not affect risk of dry or wet AMD. There was no difference in risk of wet AMD in PDR compared to NPDR. Elderly individuals with non-proliferative or proliferative diabetic retinopathy may be at higher risk of AMD compared to those without diabetes mellitus or diabetic retinopathy.