CARCINOEMBRYONIC ANTIGEN ESTIMATION IN NIPPLE DISCHARGE AS AN ADJUNCTIVE TOOL IN THE DIAGNOSIS OF EARLY BREAST-CANCER
CARCINOEMBRYONIC ANTIGEN ESTIMATION IN NIPPLE DISCHARGE AS AN ADJUNCTIVE TOOL IN THE DIAGNOSIS OF EARLY BREAST-CANCER
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DOI：
10.1002/1097-0142(19871215)60:12
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发表时间：
1987-12-15
期刊：
影响因子：
6.2
通讯作者：
MORI, T
中科院分区：
文献类型：
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作者：
INAJI, H;YAYOI, E;MORI, T
为了评估乳头溢液中癌胚抗原（CEA）评估对不可摸性乳腺癌的检测价值，采用单克隆抗体酶免疫分析法测定乳头溢液中癌胚抗原的活性。通过免疫组织化学方法评估该抗体对乳腺癌的特异性。18例乳腺良性疾病患者（10例导管内乳头状瘤，8例纤维囊性疾病）乳头溢液中CEA的平均水平为43 ng/ml (SD, 34 ng/ml)，提示参考上限为100 ng/ml。7名不可触及的乳腺癌患者中有6名CEA水平高于这个暂定临界值，5名边缘性病变患者中有3名CEA水平高于这个临界值。乳头溢液中CEA水平升高的发生率与瘤内抗原表达的发生率显著相关。这些结果使我们得出结论，乳头溢液中CEA的测量可能是诊断不可触及乳腺癌的有用辅助手段。
To assess the usefulness of carcinoembryonic antigen (CEA) estimation in nipple discharge for the detection of nonpalpable breast cancer, CEA activity in nipple discharge was measured by enzyme immunoassay using monoclonal antibody. The specificity of the antibody for breast cancer was assessed by an immunohistochemical method. Mean CEA levels in the nipple discharge from 18 patients with benign breast diseases (ten intraductal papilloma; eight fibrocystic disease) was 43 ng/ml (SD, 34 ng/ml), suggesting an upper reference limit of 100 ng/ml. Six of seven nonpalpable breast cancer patients had higher CEA levels than this tentative cutoff value, as did three of five patients with borderline lesions. The incidence of elevated CEA levels in nipple discharge correlated significantly with the incidence of intratumoral antigen expression. These results lead us to conclude that CEA measurement in nipple discharge may be a useful adjunct in the diagnosis of nonpalpable breast cancer.