Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.
Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.
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基于编码表皮生长因子的合成序列构建新型癌基因。
DOI：
10.1126/science.3492043
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Weinberg,RA
中科院分区：
文献类型：
--
作者：
Stern,DF;Hare,DL;Cecchini,MA;Weinberg,RA
自分泌模型假设促有丝分裂生长因子的组成性释放可导致不受控制的增殖和细胞转化。编码表皮生长因子的合成多核苷酸赋予细胞致瘤表型。这些细胞通过具有细胞外成分的自分泌回路的作用而转化。
The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.