Neuroprotection in Parkinson's disease: An elusive goal
Neuroprotection in Parkinson's disease: An elusive goal
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DOI：
10.1055/s-2007-971168
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Ravina, Bernard
中科院分区：
文献类型：
--
作者：
Biglan, Kevin M.;Ravina, Bernard
尽管我们对帕金森氏病的病理生理学以及疾病对环境和遗传的影响有了更多的了解，但神经保护仍然是一个难以实现的目标。没有任何干预措施被广泛接受为帕金森氏病的疾病修正。确定新的治疗靶点的持续研究可能会产生几种假定的神经保护剂。从以前的神经保护试验中吸取经验教训，将对开发未来旨在有效确定神经保护治疗方法的试验至关重要。最终，需要克服异质性、缓慢进展的疾病的独特挑战，采用多种潜在的结果衡量标准，以确定有意义的治疗方法。
Despite increases in our understanding of the pathophysiology and environmental and genetic influences of illness in Parkinson's disease, neuroprotection remains an elusive goal. No interventions are widely accepted as disease modifying in Parkinson's disease. Continued research identifying novel therapeutic targets is likely to result in several putative neuroprotective agents. Assimilating lessons from previous neuroprotection trials will be critical in developing future trials aimed at efficiently identifying neuroprotective treatments. Ultimately, overcoming the unique challenges of a heterogenous, slowly progressive disorder with multiple potential outcome measures will be necessary to identify treatments that have meaningful effects.