Contribution to regulatory science and a next challenge of the Japanese Environmental Mutagen Society (JEMS).
Contribution to regulatory science and a next challenge of the Japanese Environmental Mutagen Society (JEMS).
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DOI：
10.1186/s41021-016-0040-1
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Uno Y
中科院分区：
文献类型：
--
作者：
Uno Y
日本环境诱变剂协会（JEMS）的许多成员对化学遗传毒性的指导方针作出了重大贡献。这些准则对基因毒性化学品的危害识别和风险评估是有用的。然而，风险评估人员和药物及其他商业产品的开发人员可能仅仅根据基因毒性测试的阳性结果，就将有益化学品从进一步开发中剔除。基因毒性领域的专家应该更好地描述基因毒物的生物学意义，更正确地评估人类风险。我希望，JEMS的下一个挑战之一将是在对基因毒性化学品的作用机制进行精确分析的基础上，更准确地评估其对人类的风险。
Many members of The Japanese Environmental Mutagen Society (JEMS) have significantly contributed to guidelines on chemical genotoxicity. The guidelines have been useful for the hazard identification and risk assessment of genotoxic chemicals. However, risk assessors and developers of drugs and other commercial products might eliminate beneficial chemicals from further development simply based on positive results of genotoxicity testing. Experts in the field of genotoxicity should better characterize the biological significance of genotoxicants and more correctly assess human risk. I hope that one of the next challenges undertaken by JEMS will be to assess the human risk of genotoxic chemicals more correctly based on the precise analysis of their mechanisms of action.