SPOROZOITE VACCINE INDUCES GENETICALLY RESTRICTED T-CELL ELIMINATION OF MALARIA FROM HEPATOCYTES
SPOROZOITE VACCINE INDUCES GENETICALLY RESTRICTED T-CELL ELIMINATION OF MALARIA FROM HEPATOCYTES
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DOI：
10.1126/science.2524877
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发表时间：
1989-06-02
期刊：
影响因子：
56.9
通讯作者：
BALLOU, WR
中科院分区：
文献类型：
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作者：
HOFFMAN, SL;ISENBARGER, D;BALLOU, WR
CD8+ T细胞依赖性保护用辐照减毒疟疾孢子虫免疫的小鼠的靶标尚未确定。免疫BALB/c小鼠在受到伯氏疟原虫孢子虫攻击后，肝脏出现了疟疾特异性的CD8+ T细胞依赖性炎症浸润。免疫BALB/c和C57BL/6小鼠的脾细胞在体外可消除伯氏弓形虫肝期感染的肝细胞。抗感染肝细胞的活性不受干扰素抗体的抑制。并且不存在于培养上清液中。由于肝细胞表面的疟疾抗原可被免疫T效应细胞识别，它在遗传上受到限制。亚单位疫苗的开发将需要鉴定这些T细胞识别的抗原和一种诱导这种免疫的免疫方法。
The target of the CD8+ T cell-dependent that protects mice immunized with irradiation-attenuated malaria sporozoites has not been established. Immune BALB/c mice were shown to develop malaria-specific, CD8+ T cell-dependent inflammatory infiltrates in their livers after challenge with Plasmodium Berghei sporozoites. Spleen cells from immune BALB/c and C57BL/6 mice eliminated hepatocytes infected with the liver stage of P. berghei in vitro. The activity against infected hepatocytes is not inhibited by antibodies to interferon-.gamma. and is not present in culture supernatants. It is genetically restricted, as indication that malaria antigens on the hepatocyte surface are recognized by immune T effector cells. Subunit vaccine development will require identification of the antigens recognized by these T cells and a method of immunization that induces such immunity.