Elevated concentrations of endotoxin in indoor air due to cigarette smoking
Elevated concentrations of endotoxin in indoor air due to cigarette smoking
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DOI：
10.1039/b600706f
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Larsson, Lennart
中科院分区：
文献类型：
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作者：
Sebastian, Aleksandra;Pehrson, Christina;Larsson, Lennart
暴露于环境烟草烟雾（ETS）是一个重要的全球公共卫生问题。本研究表明，香烟烟雾可能是室内环境中内毒素（脂多糖，LPS）的主要来源。使用气相色谱/质谱法测定 3-羟基脂肪酸，作为吸烟者和非吸烟者家中空气传播的室内灰尘中内毒素的标记物。吸烟学生房间的空气内毒素浓度比不吸烟学生房间的空气浓度高4-63倍。香烟烟雾中含有大量内毒素这一事实可能部分解释了吸烟者呼吸系统疾病的高患病率，也可能引起人们对迄今为止被忽视的 ETS 危险因素的关注。
Exposure to environmental tobacco smoke (ETS) is an important worldwide public health issue. The present study demonstrates that cigarette smoke can be a major source of endotoxin (lipopolysaccharide, LPS) in indoor environments. Gas-chromatography/mass-spectrometry was used to determine 3-hydroxy fatty acids as markers of endotoxin in air-borne house dust in homes of smokers and non-smokers. Air concentrations of endotoxin were 4-63 times higher in rooms of smoking students than in identical rooms of non-smoking students. The fact that cigarette smoke contains large amounts of endotoxin may partly explain the high prevalence of respiratory disorders among smokers and may also draw attention to a hitherto neglected risk factor of ETS.