Reelin through the years: From brain development to inflammation.
Reelin through the years: From brain development to inflammation.
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DOI：
10.1016/j.celrep.2023.112669
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发表时间：
2023-06-27
期刊：
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
Reelin最初被鉴定为神经元迁移和突触功能的调节剂，但其非神经元功能受到的关注要少得多。Reelin参与各种组织的器官发育和生理功能，但在某些疾病中也失调。在心血管系统中，Reelin在血液中含量丰富，有助于血小板粘附、凝血以及血管粘附和白细胞渗透。它是一种促炎和促血栓形成因子，对自身炎症和自身免疫疾病如多发性硬化症、阿尔茨海默病、关节炎、动脉粥样硬化或癌症具有重要意义。从机制上讲，Reelin是一种大的分泌性糖蛋白，其结合几种膜受体，包括ApoER 2、VLDLR、整联蛋白和肝配蛋白。Reelin信号传导取决于细胞类型，但主要涉及NF-κB、PI 3 K、AKT或JAK/STAT的磷酸化。这篇综述着重于非神经元的功能和治疗潜力的Reelin，同时强调分泌，信号和功能的相似性细胞类型之间。
Reelin was originally identified as a regulator of neuronal migration and synaptic function, but its non-neuronal functions have received far less attention. Reelin participates in organ development and physiological functions in various tissues, but it is also dysregulated in some diseases. In the cardiovascular system, Reelin is abundant in the blood where it contributes to platelet adhesion, coagulation, as well as vascular adhesion and permeability to leukocytes. It is a pro-inflammatory and pro-thrombotic factor with important implications for auto-inflammatory and auto-immune diseases such as multiple sclerosis, Alzheimer’s disease, arthritis, atherosclerosis, or cancer. Mechanistically, Reelin is a large secreted glycoprotein that binds to several membrane receptors including ApoER2, VLDLR, integrins, and ephrins. Reelin signaling depends on the cell type but mostly involves phosphorylation of NF-κB, PI3K, AKT, or JAK/STAT. This review focuses on non-neuronal functions and the therapeutic potential of Reelin while highlighting secretion, signaling, and functional similarities between cell types.
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影响因子：
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作者：
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作者：
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